New York, Oct 8 (TIWN) As far as numbers go, Kamala Harris, the first ever Indian and African American woman on a US presidential ticket, enters Wednesday's prime time Vice Presidential debate on a high with Democratic presidential nominee Joe Biden widening his head-to-head lead against US president Donald Trump, now the country's most famous COVID-19 patient.

Pence and Harris face off Wednesday 9 p.m. EST (Thursday, 6.30 a.m. IST). They meet on the debate stage for the first and only time, in Utah.  VP debates have rarely been a lightning rod in the final bend of presidential politics, but in the last week alone, the stakes have shifted in surprising ways.  Harris' presence on the debate stage is historic, in and of itself. Harris will be looking to star in a few big moments Wednesday night to leave her mark in the annals of presidential politics. 

She did that in the Democratic primary debates by turning the clock back to her personal experience with school busing. At that time, it was to attack Biden.  Harris' introduction as VP nominee to the American public and her subsequent pitches have been deeply personal. In a pre-debate tweet, Harris said she is voting "for people like my mother, Shyamala, who taught my sister and me that if you see a problem, you don't complain about it: you do something about it. "It's because of her that I know change is possible when we put in the work."